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Translesion and Repair DNA Polymerases: Diverse Structure and Mechanism

1 Mar 2018

Abstract excerpt

The number of DNA polymerases identified in each organism has mushroomed in the past two decades. Most newly found DNA polymerases specialize in translesion synthesis and DNA repair instead of replication. Although intrinsic error rates are higher for translesion and repair polymerases than for replicative polymerases, the specialized polymerases increase genome stability and reduce tumorigenesis. Reflecting the...

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PMID: 29494238
DOI: 10.1146/annurev-biochem-062917-012405

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