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Biochemical characterization of eight genetic variants of human DNA polymerase κ involved in error-free bypass across bulky N(2)-guanyl DNA adducts.

Chemical research in toxicology - 19 May 2014

Song Insil, Kim Eun-Jin, Kim In-Hyeok, Park Eun-Mi, Lee Kyung Eun, Shin Joo-Ho, Guengerich F Peter, Choi Jeong-Yun

Abstract excerpt

DNA polymerase (pol) κ, one of the Y-family polymerases, has been shown to function in error-free translesion DNA synthesis (TLS) opposite the bulky N(2)-guanyl DNA lesions induced by many carcinogens such as polycyclic aromatic hydrocarbons. We analyzed the biochemical properties of eight reported human pol κ variants positioned in the polymerase core domain, using the recombinant pol κ (residues 1-526) protein...

Topics

DNA Adducts
DNA-Directed DNA Polymerase
Genetic Variation
Humans
Models, Molecular
Mutation
Protein Structure, Tertiary
Recombinant Proteins

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24725253
DOI: 10.1021/tx500072m
PMCID: PMC7002036

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