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Structure and mechanism of error-free replication past the major benzo[a]pyrene adduct by human DNA polymerase κ

31 Mar 2016

Abstract excerpt

Benzo[a]pyrene (BP) is a well-known and frequently encountered carcinogen which generates a bulky DNA adduct (+)-trans-10S-BP-N(2)-dG (BP-dG) in cells. DNA polymerase kappa (polκ) is the only known Y-family polymerase that bypasses BP-dG accurately and thus protects cells from genotoxic BP. Here, we report the structures of human polκ in complex with DNA containing either a normal guanine (G) base or a BP-dG...

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PMID: 27034468
DOI: 10.1093/nar/gkw204

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