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Article

Oncostatin-M differentially regulates mesenchymal and proneural signature genes in gliomas via STAT3 signaling.

Neoplasia (New York, N.Y.) - 1 Feb 2015

Natesh Kumar, Bhosale Dipali, Desai Aarti, Chandrika Goparaju, Pujari Radha, Jagtap Jayashree, Chugh Ashish, Ranade Deepak, Shastry Padma

Abstract excerpt

Glioblastoma (GBM), the most malignant of the brain tumors is classified on the basis of molecular signature genes using TCGA data into four subtypes- classical, mesenchymal, proneural and neural. The mesenchymal phenotype is associated with greater aggressiveness and low survival in contrast to GBMs enriched with proneural genes. The proinflammatory cytokines secreted in the microenvironment of gliomas play a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25748242
DOI: 10.1016/j.neo.2015.01.001
PMCID: PMC4351301

Genes

OSM
OSMR
DLL3
STAT3
BCAN
LIFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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