Article
Activation of hypoxia signaling induces phenotypic transformation of glioma cells: implications for bevacizumab antiangiogenic therapy.
Oncotarget - 20 May 2015
Xu Hui, Rahimpour Shervin, Nesvick Cody L, Zhang Xu, Ma Jingyun, Zhang Min, Zhang Ge, Wang Li, Yang Chunzhang, Hong Christopher S, Germanwala Anand V, Elder J Bradley, Ray-Chaudhury Abhik, Yao Yu, Gilbert Mark R, Lonser Russell R, Heiss John D, Brady Roscoe O, Mao Ying, Qin Jianhua, Zhuang Zhengping
Abstract excerpt
Glioblastoma (GBM) is the most common and deadly primary brain tumor in adults. Bevacizumab, a humanized monoclonal antibody against vascular endothelial growth factor (VEGF), can attenuate tumor-associated edema and improve patient symptoms but based on magnetic resonance imaging, is associated with non-enhancing tumor progression and possibly gliosarcoma differentiation. To gain insight into these findings, we...
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