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Article

CXCR4 expression is associated with proneural-to-mesenchymal transition in glioblastoma.

International journal of cancer - 15 Feb 2023

Khan A Basit, Lee Sungho, Harmanci Akdes Serin, Patel Rajan, Latha Khatri, Yang Yuhui, Marisetty Anantha, Lee Hyun-Kyoung, Heimberger Amy B, Fuller Gregory N, Deneen Benjamin, Rao Ganesh

Abstract excerpt

Glioblastoma (GBM) is the most common primary intracranial malignant tumor and consists of three molecular subtypes: proneural (PN), mesenchymal (MES) and classical (CL). Transition between PN to MES subtypes (PMT) is the glioma analog of the epithelial-mesenchymal transition (EMT) in carcinomas and is associated with resistance to therapy. CXCR4 signaling increases the expression of MES genes in glioma cell...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36250346
DOI: 10.1002/ijc.34329
PMCID: PMC10071545

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