Article
Hypoxia enhances migration and invasion in glioblastoma by promoting a mesenchymal shift mediated by the HIF1α-ZEB1 axis.
Cancer letters - 1 Apr 2015
Joseph Justin V, Conroy Siobhan, Pavlov Kirill, Sontakke Pallavi, Tomar Tushar, Eggens-Meijer Ellie, Balasubramaniyan Veerakumar, Wagemakers Michiel, den Dunnen Wilfred F A, Kruyt Frank A E
Abstract excerpt
Glioblastoma (GBM) is the most common brain tumor in adults and the mesenchymal GBM subtype was reported to be the most malignant, presenting severe hypoxia and necrosis. Here, we investigated the possible role of a hypoxic microenvironment for inducing a mesenchymal and invasive phenotype. The exposure of non-mesenchymal SNB75 and U87 cells to hypoxia induced a strong change in cell morphology that was...
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