Genome-wide association study of homocysteine in African Americans from the Jackson Heart Study, the Multi-Ethnic Study of Atherosclerosis, and the Coronary Artery Risk in Young Adults study.

doi:10.1038/s10038-017-0384-9

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Article

Genome-wide association study of homocysteine in African Americans from the Jackson Heart Study, the Multi-Ethnic Study of Atherosclerosis, and the Coronary Artery Risk in Young Adults study.

Journal of human genetics - 1 Mar 2018

Raffield Laura M, Ellis Jaclyn, Olson Nels C, Duan Qing, Li Jin, Durda Peter, Pankratz Nathan, Keating Brendan J, Wassel Christina L, Cushman Mary, Wilson James G, Gross Myron D, Tracy Russell P, Rich Stephen S, Reiner Alex P, Li Yun, Willis Monte S, Lange Ethan M, Lange Leslie A

Abstract excerpt

Homocysteine (Hcy) is a heritable biomarker for CVD, peripheral artery disease, stroke, and dementia. Little is known about genetic associations with Hcy in individuals of African ancestry. We performed a genome-wide association study for Hcy in 4927 AAs from the Jackson Heart Study (JHS), the Multi-Ethnic Study of Atherosclerosis (MESA), and the Coronary Artery Risk in Young Adults (CARDIA) study. Analyses were...

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Identifiers

PMID: 29321517
DOI: 10.1038/s10038-017-0384-9
PMCID: PMC5826839

Genes

NOX4
CBS
CPS1
MMACHC
MTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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