Article
Genome-wide meta-analysis of homocysteine and methionine metabolism identifies five one carbon metabolism loci and a novel association of ALDH1L1 with ischemic stroke.
PLoS genetics - 1 Mar 2014
Williams Stephen R, Yang Qiong, Chen Fang, Liu Xuan, Keene Keith L, Jacques Paul, Chen Wei-Min, Weinstein Galit, Hsu Fang-Chi, Beiser Alexa, Wang Liewei, Bookman Ebony, Doheny Kimberly F, Wolf Philip A, Zilka Michelle, Selhub Jacob, Nelson Sarah, Gogarten Stephanie M, Worrall Bradford B, Seshadri Sudha, Sale Michèle M
Abstract excerpt
Circulating homocysteine levels (tHcy), a product of the folate one carbon metabolism pathway (FOCM) through the demethylation of methionine, are heritable and are associated with an increased risk of common diseases such as stroke, cardiovascular disease (CVD), cancer and dementia. The FOCM is the sole source of de novo methyl group synthesis, impacting many biological and epigenetic pathways. However, the...
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