Article
Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease.
The American journal of clinical nutrition - 1 Sept 2013
van Meurs Joyce B J, Pare Guillaume, Schwartz Stephen M, Hazra Aditi, Tanaka Toshiko, Vermeulen Sita H, Cotlarciuc Ioana, Yuan Xin, Mälarstig Anders, Bandinelli Stefania, Bis Joshua C, Blom Henk, Brown Morris J, Chen Constance, Chen Yii-Der, Clarke Robert J, Dehghan Abbas, Erdmann Jeanette, Ferrucci Luigi, Hamsten Anders, Hofman Albert, Hunter David J, Goel Anuj, Johnson Andrew D, Kathiresan Sekar, Kampman Ellen, Kiel Douglas P, Kiemeney Lambertus A L M, Chambers John C, Kraft Peter, Lindemans Jan, McKnight Barbara, Nelson Christopher P, O'Donnell Christopher J, Psaty Bruce M, Ridker Paul M, Rivadeneira Fernando, Rose Lynda M, Seedorf Udo, Siscovick David S, Schunkert Heribert, Selhub Jacob, Ueland Per M, Vollenweider Peter, Waeber Gérard, Waterworth Dawn M, Watkins Hugh, Witteman Jacqueline C M, den Heijer Martin, Jacques Paul, Uitterlinden Andre G, Kooner Jaspal S, Rader Dan J, Reilly Muredach P, Mooser Vincent, Chasman Daniel I, Samani Nilesh J, Ahmadi Kourosh R
Abstract excerpt
BACKGROUND: The strong observational association between total homocysteine (tHcy) concentrations and risk of coronary artery disease (CAD) and the null associations in the homocysteine-lowering trials have prompted the need to identify genetic variants associated with homocysteine concentrations and risk of CAD. OBJECTIVE: We tested whether common genetic polymorphisms associated with variation in tHcy are also...
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