Article
Novel associations of CPS1, MUT, NOX4, and DPEP1 with plasma homocysteine in a healthy population: a genome-wide evaluation of 13 974 participants in the Women's Genome Health Study.
Circulation. Cardiovascular genetics - 1 Apr 2009
Paré Guillaume, Chasman Daniel I, Parker Alexander N, Zee Robert R Y, Mälarstig Anders, Seedorf Udo, Collins Rory, Watkins Hugh, Hamsten Anders, Miletich Joseph P, Ridker Paul M
Abstract excerpt
BACKGROUND: Homocysteine is a sulfur amino acid whose plasma concentration has been associated with the risk of cardiovascular diseases, neural tube defects, and loss of cognitive function in epidemiological studies. Although genetic variants of MTHFR and CBS are known to influence homocysteine concentration, common genetic determinants of homocysteine remain largely unknown. METHODS AND RESULTS: To address this...
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