GWAS of Folate Metabolism With Gene-environment Interaction Analysis Revealed the Possible Role of Lifestyles in the Control of Blood Folate Metabolites in Japanese: The J-MICC Study.

doi:10.2188/jea.JE20220341

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GWAS of Folate Metabolism With Gene-environment Interaction Analysis Revealed the Possible Role of Lifestyles in the Control of Blood Folate Metabolites in Japanese: The J-MICC Study.

Journal of epidemiology - 5 May 2024

Tsukamoto Mineko, Hishida Asahi, Tamura Takashi, Nagayoshi Mako, Okada Rieko, Kubo Yoko, Kato Yasufumi, Hamajima Nobuyuki, Nishida Yuichiro, Shimanoe Chisato, Ibusuki Rie, Shibuya Kenichi, Takashima Naoyuki, Nakamura Yasuyuki, Kusakabe Miho, Nakamura Yohko, Koyanagi Yuriko N, Oze Isao, Nishiyama Takeshi, Suzuki Sadao, Watanabe Isao, Matsui Daisuke, Otonari Jun, Ikezaki Hiroaki, Katsuura-Kamano Sakurako, Arisawa Kokichi, Kuriki Kiyonori, Nakatochi Masahiro, Momozawa Yukihide, Takeuchi Kenji, Wakai Kenji, Matsuo Keitaro

Abstract excerpt

BACKGROUND: The present genome-wide association study (GWAS) aimed to reveal the genetic loci associated with folate metabolites, as well as to detect related gene-environment interactions in Japanese. METHODS: We conducted the GWAS of plasma homocysteine (Hcy), folic acid (FA), and vitamin B12 (VB12) levels in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study participants who joined from 2005 to...

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PMID: 37517992
DOI: 10.2188/jea.JE20220341
PMCID: PMC10999522

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