Article
Identification of ZNF366 and PTPRD as novel determinants of plasma homocysteine in a family-based genome-wide association study.
Blood - 13 Aug 2009
Mälarstig Anders, Buil Alfonso, Souto Juan Carolos, Clarke Robert, Blanco-Vaca Francisco, Fontcuberta Jordi, Peden John, Andersen Malin, Silveira Angela, Barlera Simona, Seedorf Udo, Watkins Hugh, Almasy Laura, Hamsten Anders, Soria José Manuel
Abstract excerpt
Total plasma homocysteine concentration (tHcy) is a biomarker for atherothrombotic disease, but causality remains uncertain. Polymorphisms in the genes involved in methionine metabolism explain only a small fraction of the heritability of tHcy levels. In a genome-wide association study, we examined the genetic determinants of tHcy using a 2-stage design. First, 283 437 single nucleotide polymorphisms (SNPs) were...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.