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Article

Folate network genetic variation predicts cardiovascular disease risk in non-Hispanic white males.

The Journal of nutrition - 1 Jul 2012

Wernimont Susan M, Clark Andrew G, Stover Patrick J, Wells Martin T, Litonjua Augusto A, Weiss Scott T, Gaziano J Michael, Vokonas Pantel S, Tucker Katherine L, Cassano Patricia A

Abstract excerpt

Genes functioning in folate-mediated 1-carbon metabolism are hypothesized to play a role in cardiovascular disease (CVD) risk beyond the current narrow focus on the MTHFR 677 C→T (rs1801133) polymorphism. Using a cohort study design, we investigated whether sequence variants in the network of folate-related genes, particularly in genes encoding proteins related to SHMT1, predict CVD risk in 1131 men from the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22649255
DOI: 10.3945/jn.111.157180
PMCID: PMC3374665

Genes

MTHFR
SHMT1
TYMS
BHMT
CELF1
FTH1
GGH

Provenance

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