Article
Cell-cell contact interactions conditionally determine suppression and selection of the neoplastic phenotype.
Proceedings of the National Academy of Sciences of the United States of America - 29 Apr 2008
Rubin Harry
Abstract excerpt
Separation of chemical and physical carcinogenesis into the stages of initiation (mutation) and promotion (selection) established that incipient neoplastic cells could persist in the organism indefinitely without expression. Spontaneous mutations associated with cancer also lie dormant in untreated normal tissue. Without selection, there is no tumor development. Experiments in cell culture showed that confluent...
Topics
- Animals
- Cell Communication
- Cell Proliferation
- Cell Transformation, Neoplastic
- Cells, Cultured
- Mice
- Mutation
- NIH 3T3 Cells
- Neoplasms
- Phenotype