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Article

Cell-cell contact interactions conditionally determine suppression and selection of the neoplastic phenotype.

Proceedings of the National Academy of Sciences of the United States of America - 29 Apr 2008

Rubin Harry

Abstract excerpt

Separation of chemical and physical carcinogenesis into the stages of initiation (mutation) and promotion (selection) established that incipient neoplastic cells could persist in the organism indefinitely without expression. Spontaneous mutations associated with cancer also lie dormant in untreated normal tissue. Without selection, there is no tumor development. Experiments in cell culture showed that confluent...

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Identifiers

PMID: 18434545
DOI: 10.1073/pnas.0800747105
PMCID: PMC2359782

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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