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Article

Multiple Chemical Inducible Tal Effectors for Genome Editing and Transcription Activation.

ACS chemical biology - 16 Mar 2018

Zhao Chen, Zhang Yue, Zhao Yingze, Ying Yue, Ai Runna, Zhang Jingfang, Wang Yu

Abstract excerpt

Inducible modulation is often required for precise investigations and manipulations of dynamic biological processes. Transcription activator-like effectors (TALEs) provide a powerful tool for targeted gene editing and transcriptional programming. We designed a series of chemical inducible systems by coupling TALEs with a mutated human estrogen receptor (ERT2), which renders them 4-hydroxyl-tamoxifen (4-OHT)...

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PMID: 29308880
DOI: 10.1021/acschembio.7b00606

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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