Article
Multimode drug inducible CRISPR/Cas9 devices for transcriptional activation and genome editing.
Nucleic acids research - 16 Mar 2018
Lu Jia, Zhao Chen, Zhao Yingze, Zhang Jingfang, Zhang Yue, Chen Li, Han Qiyuan, Ying Yue, Peng Shuai, Ai Runna, Wang Yu
Abstract excerpt
Precise investigation and manipulation of dynamic biological processes often requires molecular modulation in a controlled inducible manner. The clustered, regularly interspaced, short palindromic repeats (CRISPR)/CRISPR associated protein 9 (Cas9) has emerged as a versatile tool for targeted gene editing and transcriptional programming. Here, we designed and vigorously optimized a series of Hybrid drug Inducible...
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