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Article

The phosphatidylinositide 3-kinase (PI3K) signaling pathway is a determinant of zileuton response in adults with asthma.

The pharmacogenomics journal - 1 Sept 2018

Dahlin Amber, Qiu Weiliang, Litonjua Augusto A, Lima John J, Tamari Mayumi, Kubo Michiaki, Irvin Charles G, Peters Stephen P, Wu Ann C, Weiss Scott T, Tantisira Kelan G

Abstract excerpt

Variable responsiveness to zileuton, a leukotriene antagonist used to treat asthma, may be due in part to genetic variation. While individual SNPs were previously associated with zileuton-related lung function changes, specific quantitative trait loci (QTLs) and biological pathways that may contribute have not been identified. In this study, we investigated the hypothesis that genetic variation within biological...

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Identifiers

PMID: 29298996
DOI: 10.1038/s41397-017-0006-0
PMCID: PMC6150906

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SELL

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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