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Leukotriene pathway genetics and pharmacogenetics in allergy

30 Mar 2009

Abstract excerpt

Leukotrienes (LT) are biologically active lipid mediators known to be involved in allergic inflammation. Leukotrienes have been shown to mediate diverse features of allergic conditions including inflammatory cell chemotaxis/activation and smooth muscle contraction. Cysteinyl leukotrienes (LTC(4), LTD(4) and, LTE(4)) and the dihydroxy leukotriene LTB(4) are generated by a series of enzymes/proteins constituting...

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PMID: 19416143
DOI: 10.1111/j.1398-9995.2009.02015.x

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