Article
Pharmacogenomics: novel loci identification via integrating gene differential analysis and eQTL analysis.
Human molecular genetics - 15 Sept 2014
Qiu Weiliang, Rogers Angela J, Damask Amy, Raby Benjamin A, Klanderman Barbara J, Duan Qing Ling, Tyagi Shiva, Niu Simin, Anderson Christopher, Cahir-Mcfarland Ellen, Mariani Thomas J, Carey Vincent, Tantisira Kelan G
Abstract excerpt
Nearly one-half of asthmatic patients do not respond to the most commonly prescribed controller therapy, inhaled corticosteroids (ICS). We conducted an expression quantitative trait loci (eQTL) analysis using >300 expression microarrays (from 117 lymphoblastoid cell lines) in corticosteroid (dexamethasone) treated and untreated cells derived from asthmatic subjects in the Childhood Asthma Management Program...
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