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Article

Genome-Wide Association Study Identifies Novel Pharmacogenomic Loci For Therapeutic Response to Montelukast in Asthma.

PloS one - 1 Jan 2015

Dahlin Amber, Litonjua Augusto, Lima John J, Tamari Mayumi, Kubo Michiaki, Irvin Charles G, Peters Stephen P, Tantisira Kelan G

Abstract excerpt

BACKGROUND: Genome-wide association study (GWAS) is a powerful tool to identify novel pharmacogenetic single nucleotide polymorphisms (SNPs). Leukotriene receptor antagonists (LTRAs) are a major class of asthma medications, and genetic factors contribute to variable responses to these drugs. We used GWAS to identify novel SNPs associated with the response to the LTRA, montelukast, in asthmatics. METHODS: Using...

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Identifiers

PMID: 26083242
DOI: 10.1371/journal.pone.0129385
PMCID: PMC4470685

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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