Article
Pharmacogenetics of the 5-lipoxygenase pathway in asthma.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Nov 1998
Silverman E, In K H, Yandava C, Drazen J M
Abstract excerpt
It is now well appreciated that asthma is a chronic inflammatory disease of the airways; among the inflammatory cells that have been implicated in the asthmatic lesion are eosinophils and mast cells. Although these cells have the capacity to produce a number of distinct chemical mediators, the cysteinyl leukotrienes have recently been identified as important mediators of the asthmatic response. The leukotrienes...
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