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Cysteinyl Leukotrienes Pathway Genes, Atopic Asthma and Drug Response: From Population Isolates to Large Genome-Wide Association Studies

1 Dec 2016

Abstract excerpt

Genetic studies have identified genetic variants associated with asthma pathogenesis and altered response to drug therapy. Many studies implicate polymorphisms in genes encoding the enzymes responsible for leukotriene synthesis and intracellular signaling through activation of seven transmembrane domain receptors, such as the cysteinyl leukotriene 1 (CYSLTR1) and 2 (CYSLTR2) receptors. The leukotrienes are...

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PMID: 27990118
DOI: 10.3389/fphar.2016.00299

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