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Article

Pharmacogenetics of the 5-lipoxygenase biosynthetic pathway and variable clinical response to montelukast

1 Mar 2007

Abstract excerpt

OBJECTIVE: Interindividual clinical response to leukotriene modifiers is highly variable, and less efficacious than inhaled corticosteroids in treating asthma. Genetic variability in 5-lipoxygenase biosynthetic and receptor pathway gene loci may influence cysteinyl-leukotriene production and subsequent response to leukotriene modifiers. METHODS: Using data from two clinical trials of 12-week duration, post-hoc...

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PMID: 17460547
DOI: 10.1097/fpc.0b013e3280120043

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