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Article

5-lipoxygenase pharmacogenetics in asthma: overlap with Cys-leukotriene receptor antagonist loci.

Pharmacogenetics and genomics - 1 Mar 2009

Tantisira Kelan G, Lima John, Sylvia Jody, Klanderman Barbara, Weiss Scott T

Abstract excerpt

The two classes of leukotriene modifiers work by inhibiting different portions of the same pathway. We hypothesized that single nucleotide polymorphisms (SNPs) in genes associated with response to montelukast (a cys-leukotriene receptor antagonist) would also be associated with response to zileuton (a 5-lipoxygenase inhibitor). We genotyped 26 SNPs that had previously been interrogated for association with...

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Identifiers

PMID: 19214143
DOI: 10.1097/FPC.0b013e328326e0b1
PMCID: PMC2731688

Genes

ABCC1
ALOX5
CYSLTR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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