Article
Genome-wide association study of leukotriene modifier response in asthma.
The pharmacogenomics journal - 1 Apr 2016
Dahlin A, Litonjua A, Irvin C G, Peters S P, Lima J J, Kubo M, Tamari M, Tantisira K G
Abstract excerpt
Heterogeneous therapeutic responses to leukotriene modifiers (LTMs) are likely due to variation in patient genetics. Although prior candidate gene studies implicated multiple pharmacogenetic loci, to date, no genome-wide association study (GWAS) of LTM response was reported. In this study, DNA and phenotypic information from two placebo-controlled trials (total N=526) of zileuton response were interrogated. Using...
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