Article
ERK-mediated phosphorylation regulates SOX10 sumoylation and targets expression in mutant BRAF melanoma.
Nature communications - 2 Jan 2018
Han Shujun, Ren Yibo, He Wangxiao, Liu Huadong, Zhi Zhe, Zhu Xinliang, Yang Tielin, Rong Yu, Ma Bohan, Purwin Timothy J, Ouyang Zhenlin, Li Caixia, Wang Xun, Wang Xueqiang, Yang Huizi, Zheng Yan, Aplin Andrew E, Liu Jiankang, Shao Yongping
Abstract excerpt
In human mutant BRAF melanoma cells, the stemness transcription factor FOXD3 is rapidly induced by inhibition of ERK1/2 signaling and mediates adaptive resistance to RAF inhibitors. However, the mechanism underlying ERK signaling control of FOXD3 expression remains unknown. Here we show that SOX10 is both necessary and sufficient for RAF inhibitor-induced expression of FOXD3 in mutant BRAF melanoma cells. SOX10...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.