Article
Sox9 Controls Self-Renewal of Oncogene Targeted Cells and Links Tumor Initiation and Invasion.
Cell stem cell - 2 Jul 2015
Larsimont Jean-Christophe, Youssef Khalil Kass, Sánchez-Danés Adriana, Sukumaran Vijayakumar, Defrance Matthieu, Delatte Benjamin, Liagre Mélanie, Baatsen Pieter, Marine Jean-Christophe, Lippens Saskia, Guerin Christopher, Del Marmol Véronique, Vanderwinden Jean-Marie, Fuks Francois, Blanpain Cédric
Abstract excerpt
Sox9 is a transcription factor expressed in most solid tumors. However, the molecular mechanisms underlying Sox9 function during tumorigenesis remain unclear. Here, using a genetic mouse model of basal cell carcinoma (BCC), the most frequent cancer in humans, we show that Sox9 is expressed from the earliest step of tumor formation in a Wnt/β-catenin-dependent manner. Deletion of Sox9 together with the...
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