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Article

SOX2 expression is regulated by BRAF and contributes to poor patient prognosis in colorectal cancer.

PloS one - 1 Jan 2014

Lundberg Ida V, Löfgren Burström Anna, Edin Sofia, Eklöf Vincy, Öberg Åke, Stenling Roger, Palmqvist Richard, Wikberg Maria L

Abstract excerpt

Sporadic colorectal cancer (CRC) is a common malignancy and also one of the main causes of cancer deaths worldwide. Aberrant expression of the transcription factor SOX2 has recently been observed in several cancer types, but its role in CRC has not been fully elucidated. Here we studied the expression of SOX2 in 441 CRC patients by immunohistochemistry and related the expression to clinicopathological and...

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Share to Colorectal Neoplasms
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neoplasm Grading

Share to Neoplasm Staging

Share to Proto-Oncogene Proteins B-raf

Share to Receptor, Fibroblast Growth Factor, Type 1

Share to SOXB1 Transcription Factors

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Source

Open in PubMed Open full text

Identifiers

PMID: 25010701
DOI: 10.1371/journal.pone.0101957
PMCID: PMC4092103

Genes

SOX2
BRAF
FGFR1
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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