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Article

Oncogenicity of the Developmental Transcription Factor Sox9

14 Jan 2012

Abstract excerpt

SOX9 [sex-determining region Y (SRY)-box 9 protein], a high mobility group box transcription factor, plays critical roles during embryogenesis and its activity is required for development, differentiation, and lineage commitment in various tissues including the intestinal epithelium. Here, we present functional and clinical data of a broadly important role for SOX9 in tumorigenesis. SOX9 was overexpressed in a...

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Share to Epigenetics and DNA Methylation
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PMID: 22246670
DOI: 10.1158/0008-5472.can-11-3660

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