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Article

SOX10 Regulates Melanoma Immunogenicity through an IRF4–IRF1 Axis

2 Nov 2021

Abstract excerpt

Loss-of-function mutations of JAK1/2 impair cancer cell responsiveness to IFNγ and immunogenicity. Therefore, an understanding of compensatory pathways to activate IFNγ signaling in cancer cells is clinically important for the success of immunotherapy. Here we demonstrate that the transcription factor SOX10 hinders immunogenicity of melanoma cells through the IRF4-IRF1 axis. Genetic and pharmacologic approaches...

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PMID: 34728538
DOI: 10.1158/0008-5472.can-21-2078

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