Article

Semaphorin3F reduces vascular endothelial and smooth muscle cell PI3K activation and decreases neointimal plaque formation

2022-03-24

Abstract excerpt

We previously conducted genetic analyses, and identified semaphorin signaling as associating with coronary artery disease. Of the semaphorins, human vascular expression profiling suggested SEMA3F as potentially linked to atherogenesis. In hyperlipidemic mice, SEMA3F reduced aortic lesion area, and increased fibrous cap endothelial content, leading to plaque stability. In a disturbed-flow-mediated endothelial dysf...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 50c42434-604d-5071-b480-7ebdb4cb1427
DOI: 10.1101/2022.03.22.485288

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Semaphorin3F reduces vascular endothelial and smooth muscle cell PI3K activation and decreases neointimal plaque formationDOI 10.1101/2022.03.22.485288Read

Semaphorins and Their Receptors: From Axonal Guidance to AtherosclerosisSemantic proximity Read

Genetic Regulation of Atherosclerosis-Relevant Phenotypes in Human Vascular Smooth Muscle Cells.Semantic proximity Read

DKK3 (Dickkopf 3) Alters Atherosclerotic Plaque Phenotype Involving Vascular Progenitor and Fibroblast Differentiation Into Smooth Muscle Cells.Semantic proximity Read

MFAP4 Promotes Vascular Smooth Muscle Migration, Proliferation and Accelerates Neointima Formation.Semantic proximity Read

MIA SH3 Domain ER Export Factor 3 Deficiency Prevents Neointimal Formation by Restoring BAT-Like PVAT and Decreasing VSMC Proliferation and Migration.Semantic proximity Read

Differential endothelial transcriptomics identifies semaphorin 3G as a vascular class 3 semaphorin.Semantic proximity Read

Class 3 semaphorins in cardiovascular development.Semantic proximity Read

Functional investigation of the coronary artery disease gene SVEP1.Semantic proximity Read

The calcium binding protein S100β marks hedgehog-responsive resident vascular stem cells within vascular lesionsSemantic proximity Read

Sprouty1 has a protective role in atherogenesis and modifies the migratory and inflammatory phenotype of vascular smooth muscle cells.Semantic proximity Read

Endothelial Gata6 deletion reduces monocyte recruitment and proinflammatory macrophage formation and attenuates atherosclerosis through Cmpk2-Nlrp3 pathwaysSemantic proximity Read

1-Phosphatidylinositol 3-Phosphate 5-Kinase Inhibition by Apilimod Promotes an Adipocyte-Like Vascular Smooth Muscle Cell Phenotype and Prevents Arterial Calcification.Semantic proximity Read