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Article

Influence of BCL2L11 polymorphism on osteonecrosis during treatment of childhood acute lymphoblastic leukemia.

The pharmacogenomics journal - 1 Feb 2019

Plesa Maria, Gagné Vincent, Glisovic Sanja, Younan Melissa, Sharif-Askari Bahram, Laverdière Caroline, Alos Nathalie, Leclerc Jean-Marie, Sallan Stephen E, Neuberg Donna, Kutok Jeffery L, Silverman Lewis B, Sinnett Daniel, Krajinovic Maja

Abstract excerpt

Osteonecrosis (ON) is corticosteroid-related complication, reported in children with acute lymphoblastic leukemia (ALL). We have previously found that polymorphisms in BCL2L11 gene coding for pro-apoptotic Bim protein influence reduction of overall survival (OS) in a corticosteroid (CS) dose-dependent manner in childhood ALL patients. The same set of SNPs was here investigated for an association with CS-related...

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Identifiers

PMID: 29282361
DOI: 10.1038/s41397-017-0002-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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