Article
Genetic risk factors for the development of osteonecrosis in children under age 10 treated for acute lymphoblastic leukemia.
Blood - 4 Feb 2016
Karol Seth E, Mattano Leonard A, Yang Wenjian, Maloney Kelly W, Smith Colton, Liu ChengCheng, Ramsey Laura B, Fernandez Christian A, Chang Tamara Y, Neale Geoffrey, Cheng Cheng, Mardis Elaine, Fulton Robert, Scheet Paul, San Lucas F Anthony, Larsen Eric C, Loh Mignon L, Raetz Elizabeth A, Hunger Stephen P, Devidas Meenakshi, Relling Mary V
Abstract excerpt
Osteonecrosis is a dose-limiting toxicity in the treatment of pediatric acute lymphoblastic leukemia (ALL). Prior studies on the genetics of osteonecrosis have focused on patients ≥10 years of age, leaving the genetic risk factors for the larger group of children <10 years incompletely understood. Here, we perform the first evaluation of genetic risk factors for osteonecrosis in children <10 years. The discovery...
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