Article
Genetic polymorphism of vitamin D receptors and plasminogen activator inhibitor-1 and osteonecrosis risk in childhood acute lymphoblastic leukemia.
Molecular genetics & genomic medicine - 1 Jul 2021
Sherief Laila M, Beshir Mohamed, Raafat Nermin, Abdelkhalek Elhamy R, Mokhtar Wesam A, Elgerby Khaled M, Soliman Basma K, Salah Hosam E, Mokhtar Ghada A, Kamal Naglaa M, ELsayed Heba, Zakaria Marwa
Abstract excerpt
BACKGROUND: Osteonecrosis (ON) is one of the major therapy-related complications in childhood acute lymphoblastic leukemia (ALL). The purpose of the current study is to assess the frequency of ON in children with ALL and to detect whether polymorphisms in vitamin D receptor gene (VDR) and plasminogen activator inhibitor-1 (PAI-1) gene can affect the risk of ON. PATIENTS AND METHODS: Nighty-six ALL children were...
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