Article
Genetics of glucocorticoid-associated osteonecrosis in children with acute lymphoblastic leukemia.
Blood - 8 Oct 2015
Karol Seth E, Yang Wenjian, Van Driest Sara L, Chang Tamara Y, Kaste Sue, Bowton Erica, Basford Melissa, Bastarache Lisa, Roden Dan M, Denny Joshua C, Larsen Eric, Winick Naomi, Carroll William L, Cheng Cheng, Pei Deqing, Fernandez Christian A, Liu Chengcheng, Smith Colton, Loh Mignon L, Raetz Elizabeth A, Hunger Stephen P, Scheet Paul, Jeha Sima, Pui Ching-Hon, Evans William E, Devidas Meenakshi, Mattano Leonard A, Relling Mary V
Abstract excerpt
Glucocorticoids are important therapy for acute lymphoblastic leukemia (ALL) and their major adverse effect is osteonecrosis. Our goal was to identify genetic and nongenetic risk factors for osteonecrosis. We performed a genome-wide association study of single nucleotide polymorphisms (SNPs) in a discovery cohort comprising 2285 children with ALL, treated on the Children's Oncology Group AALL0232 protocol...
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