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Article

Genetic Determinants of Treatment-Related Bone Toxicity in Pediatric Acute Lymphoblastic Leukemia.

Clinical pharmacology and therapeutics - 1 Sept 2026

Abaji Rachid, Gagné Vincent, Espagne Émilie, Alos Nathalie, Del Vecchio Veronica, Ait Said Lamia, Shalmiev Albert, Fuchs Claire, Laverdière Caroline, Leclerc Jean-Marie, Sallan Stephen E, Silverman Lewis B, Sinnett Daniel, Tran Thai Hoa, Krajinovic Maja

Abstract excerpt

Osteonecrosis and fractures are serious corticosteroid-induced bone toxicities in children treated for acute lymphoblastic leukemia, yet their genetic determinants remain incompletely defined. In this study, we aimed to identify novel genetic contributors to bone toxicity and to evaluate the robustness of both newly identified and previously established risk genotypes in more recent Dana-Farber Cancer Institute...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42325004
DOI: 10.1002/cpt.70371
PMCID: PMC13339436

Genes

PGAP2
ACP1
BCL2L11
SH3YL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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