Article
RSK is a principal effector of the RAS-ERK pathway for eliciting a coordinate promotile/invasive gene program and phenotype in epithelial cells.
Molecular cell - 28 Aug 2009
Doehn Ulrik, Hauge Camilla, Frank Scott R, Jensen Claus J, Duda Katarzyna, Nielsen Jakob V, Cohen Michael S, Johansen Jens V, Winther Benny R, Lund Leif R, Winther Ole, Taunton Jack, Hansen Steen H, Frödin Morten
Abstract excerpt
The RAS-stimulated RAF-MEK-ERK pathway confers epithelial cells with critical motile and invasive capacities during development, tissue regeneration, and carcinoma progression, often via promoting the epithelial-mesenchymal transition (EMT). Many mechanisms by which ERK exerts this control remain elusive. We demonstrate that the ERK-activated kinase RSK is necessary to induce mesenchymal motility and invasive...
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