Article
SH3P2 is a negative regulator of cell motility whose function is inhibited by ribosomal S6 kinase-mediated phosphorylation.
Genes to cells : devoted to molecular & cellular mechanisms - 1 May 2011
Tanimura Susumu, Hashizume Junya, Kurosaki Yukiko, Sei Kanako, Gotoh Aiko, Ohtake Rika, Kawano Michihiro, Watanabe Kazushi, Kohno Michiaki
Abstract excerpt
Although the extracellular signal-regulated kinase (ERK) pathway functions downstream of Ras in induction of the cell motility response, the detailed molecular mechanism by which this pathway regulates cell motility has remained elusive. The application of a functional expression cloning strategy to discover proteins that regulate cell motility has resulted in the identification of an SH3 domain-containing...
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