Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Magnolin inhibits cell migration and invasion by targeting the ERKs/RSK2 signaling pathway

7 Aug 2015

Abstract excerpt

BACKGROUND: Magnolin is a natural compound abundantly found in Magnolia flos, which has been traditionally used in oriental medicine to treat headaches, nasal congestion and anti-inflammatory reactions. Our recent results have demonstrated that magnolin targets the active pockets of ERK1 and ERK2, which are important signaling molecules in cancer cell metastasis. The aim of this study is to evaluate the effects...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma
Share to Cell Transdifferentiation
Share to Extracellular Signal-Regulated MAP Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mesoderm

Share to Neoplasm Invasiveness

Share to Proto-Oncogene Proteins c-fos

Share to Ribosomal Protein S6 Kinases, 90-kDa

Share to Transduction, Genetic

Source

Identifiers

PMID: 26253302
DOI: 10.1186/s12885-015-1580-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Magnolin inhibits cell migration and invasion by targeting the ERKs/RSK2 signaling pathwayPMID 26253302Read ↗

RSK is a principal effector of the RAS-ERK pathway for eliciting a coordinate promotile/invasive gene program and phenotype in epithelial cells.Semantic proximity Read ↗

RSK2 drives cell motility by serine phosphorylation of LARG and activation of Rho GTPases.Semantic proximity Read ↗

ERK2 regulates epithelial-to-mesenchymal plasticity through DOCK10-dependent Rac1/FoxO1 activationSemantic proximity Read ↗

GEP100/Arf6 Is Required for Epidermal Growth Factor-Induced ERK/Rac1 Signaling and Cell Migration in Human Hepatoma HepG2 CellsSemantic proximity Read ↗

Pedunculoside inhibits epithelial-mesenchymal transition and overcomes Gefitinib-resistant non-small cell lung cancer through regulating MAPK and Nrf2 pathwaysSemantic proximity Read ↗

Traditional Plant‐Derived Compounds Inhibit Cell Migration and Induce Novel Cytoskeletal Effects in Glioblastoma CellsSemantic proximity Read ↗

Traditional Plant-Derived Compounds Inhibit Cell Migration and Induce Novel Cytoskeletal Effects in Glioblastoma CellsSemantic proximity Read ↗

The lichen secondary metabolite atranorin suppresses lung cancer cell motility and tumorigenesisSemantic proximity Read ↗

ERK1 Is a Regulatory Kinase Coordinating ERK2 Function in Colon AdenocarcinomaSemantic proximity Read ↗

Activation of NF‐κB by extracellular S100A4: Analysis of signal transduction mechanisms and identification of target genesSemantic proximity Read ↗

Treatment of keloids through Runx2 siRNA‑induced inhibition of the PI3K/AKT signaling pathwaySemantic proximity Read ↗

Harmine suppresses the proliferation and migration of human ovarian cancer cells through inhibiting ERK/CREB pathwaySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.