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Current Progress and Future Perspectives of Immune Checkpoint in Cancer and Infectious Diseases

30 Nov 2021

Abstract excerpt

The inhibitory regulators, known as immune checkpoints, prevent overreaction of the immune system, avoid normal tissue damage, and maintain immune homeostasis during the antimicrobial or antiviral immune response. Unfortunately, cancer cells can mimic the ligands of immune checkpoints to evade immune surveillance. Application of immune checkpoint blockade can help dampen the ligands expressed on cancer cells,...

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PMID: 34917131
DOI: 10.3389/fgene.2021.785153

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