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Article

NCOR1 modulates erythroid disorders caused by mutations of thyroid hormone receptor α1.

Scientific reports - 22 Dec 2017

Han Cho Rong, Park Sunmi, Cheng Sheue-Yann

Abstract excerpt

Thyroid hormone receptor α (THRA) gene mutations, via dominant negative mode, cause erythroid abnormalities in patients. Using mice expressing a dominant negative TRα1 mutant (TRα1PV; Thra1 PV/+ mice), we showed that TRα1PV acted directly to suppress the expression of key erythroid genes, causing erythroid defects. The nuclear receptor corepressor 1 (NCOR1) was reported to mediate the dominant negative effects of...

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Source

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Identifiers

PMID: 29273766
DOI: 10.1038/s41598-017-18409-4
PMCID: PMC5741760

Genes

NCOR1
THRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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