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Article

Nuclear receptor corepressor (NCOR1) regulates in vivo actions of a mutated thyroid hormone receptor α.

Proceedings of the National Academy of Sciences of the United States of America - 7 May 2013

Fozzatti Laura, Kim Dong Wook, Park Jeong Won, Willingham Mark C, Hollenberg Anthony N, Cheng Sheue-Yann

Abstract excerpt

Genetic evidence from patients with mutations of the thyroid hormone receptor α gene (THRA) indicates that the dominant negative activity of mutants underlies the pathological manifestations. However, the molecular mechanisms by which TRα1 mutants exert dominant negative activity in vivo are not clear. We tested the hypothesis that the severe hypothyroidism in patients with THRA mutations is due to an inability...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23610395
DOI: 10.1073/pnas.1222334110
PMCID: PMC3651436

Genes

NCOR1
THRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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