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Article

Thyroid Hormone Receptor α1 Mutants Impair B Lymphocyte Development in a Mouse Model.

Thyroid : official journal of the American Thyroid Association - 1 Jun 2021

Park Sunmi, Zhu Xuguang, Kim Minjun, Zhao Li, Cheng Sheue-Yann

Abstract excerpt

Background: Mutations of the thyroid hormone receptor α (THRA) gene cause resistance to thyroid hormone (RTHα). RTHα patients exhibit very mild abnormal thyroid function test results (serum triiodothyronine can be high-normal to high; thyroxine normal to low; thyrotropin is normal or mildly raised) but manifest hypothyroid symptoms with growth retardation, delayed bone development, and anemia. Much has been...

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Source

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Identifiers

PMID: 33267733
DOI: 10.1089/thy.2019.0782
PMCID: PMC8349714

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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