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Article

The orphan nuclear receptor TR4 regulates erythroid cell proliferation and maturation.

Blood - 7 Dec 2017

Lee Mary P, Tanabe Osamu, Shi Lihong, Jearawiriyapaisarn Natee, Lucas Daniel, Engel James Douglas

Abstract excerpt

The orphan nuclear receptors TR4 (NR2C2) and TR2 (NR2C1) are the DNA-binding subunits of the macromolecular complex, direct repeat erythroid-definitive, which has been shown to repress ε- and γ-globin transcription during adult definitive erythropoiesis. Previous studies implied that TR2 and TR4 act largely in a redundant manner during erythroid differentiation; however, during the course of routine genetic...

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Identifiers

PMID: 29018082
DOI: 10.1182/blood-2017-05-783159
PMCID: PMC5721283

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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