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Article

Resistance to thyroid hormone is modulated in vivo by the nuclear receptor corepressor (NCOR1).

Proceedings of the National Academy of Sciences of the United States of America - 18 Oct 2011

Fozzatti Laura, Lu Changxue, Kim Dong Wook, Park Jeong Won, Astapova Inna, Gavrilova Oksana, Willingham Mark C, Hollenberg Anthony N, Cheng Sheue-yann

Abstract excerpt

Mutations in the ligand-binding domain of the thyroid hormone receptor β (TRβ) lead to resistance to thyroid hormone (RTH). These TRβ mutants function in a dominant-negative fashion to interfere with the transcription activity of wild-type thyroid hormone receptors (TRs), leading to dysregulation of the pituitary-thyroid axis and resistance in peripheral tissues. The molecular mechanism by which TRβ mutants cause...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21987803
DOI: 10.1073/pnas.1107474108
PMCID: PMC3198316

Genes

NCOR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Resistance to thyroid hormone is modulated in vivo by the nuclear receptor corepressor (NCOR1).PMID 21987803Read ↗

Nuclear receptor corepressor (NCOR1) regulates in vivo actions of a mutated thyroid hormone receptor α.Semantic proximity Read ↗

Compensatory role of thyroid hormone receptor (TR) alpha 1 in resistance to thyroid hormone: study in mice with a targeted mutation in the TR beta gene and deficient in TR alpha 1.Semantic proximity Read ↗

Thyroid hormone signaling in vivo requires a balance between coactivators and corepressors.Semantic proximity Read ↗

Mice with a targeted mutation in the thyroid hormone beta receptor gene exhibit impaired growth and resistance to thyroid hormone.Semantic proximity Read ↗

Transgenic mice bearing a human mutant thyroid hormone beta 1 receptor manifest thyroid function anomalies, weight reduction, and hyperactivity.Semantic proximity Read ↗

Marked potentiation of the dominant negative action of a mutant thyroid hormone receptor beta in mice by the ablation of one wild-type beta allele.Semantic proximity Read ↗

Thyroid hormone resistance syndrome manifests as an aberrant interaction between mutant T3 receptors and transcriptional corepressors.Semantic proximity Read ↗

A resistance to thyroid hormone syndrome mutant operates through the target gene repertoire of the wild-type thyroid hormone receptor.Semantic proximity Read ↗

Nuclear corepressors enhance the dominant negative activity of mutant receptors that cause resistance to thyroid hormone.Semantic proximity Read ↗

Resistance to thyroid hormone (RTH) syndrome reveals novel determinants regulating interaction of T3 receptor with corepressor.Semantic proximity Read ↗

A Novel TRβ Mutation (R383H) in Resistance to Thyroid Hormone Syndrome Predominantly Impairs Corepressor Release and Negative Transcriptional RegulationSemantic proximity Read ↗

Thyroid hormone receptor mutations and disease: beyond thyroid hormone resistance.Semantic proximity Read ↗

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