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Article

The Impact of Carboxylesterases in Drug Metabolism and Pharmacokinetics

21 Aug 2018

Abstract excerpt

BACKGROUND: Carboxylesterases (CES) play a critical role in catalyzing hydrolysis of esters, amides, carbamates and thioesters, as well as bioconverting prodrugs and soft drugs. The unique tissue distribution of CES enzymes provides great opportunities to design prodrugs or soft drugs for tissue targeting. Marked species differences in CES tissue distribution and catalytic activity are particularly challenging in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 30129408
DOI: 10.2174/1389200219666180821094502

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