Article
Clinically relevant genetic variations in drug metabolizing enzymes.
Current drug metabolism - 1 Jun 2011
Pinto Navin, Dolan M Eileen
Abstract excerpt
In the field of pharmacogenetics, we currently have a few markers to guide physicians as to the best course of therapy for patients. For the most part, these genetic variants are within a drug metabolizing enzyme that has a large effect on the degree or rate at which a drug is converted to its metabolites. For many drugs, response and toxicity are multi-genic traits and understanding relationships between a...
Topics
- Biomarkers, Pharmacological
- Drug Labeling
- Drug Therapy
- Drug-Related Side Effects and Adverse Reactions
- Genetic Variation
- Humans
- Inactivation, Metabolic
- Pharmaceutical Preparations
- Pharmacogenetics
- United States
- United States Food and Drug Administration