Article
Clinically relevant genetic variations in drug metabolizing enzymes.
Current drug metabolism - 1 Jun 2011
Pinto Navin, Dolan M Eileen
Abstract excerpt
In the field of pharmacogenetics, we currently have a few markers to guide physicians as to the best course of therapy for patients. For the most part, these genetic variants are within a drug metabolizing enzyme that has a large effect on the degree or rate at which a drug is converted to its metabolites. For many drugs, response and toxicity are multi-genic traits and understanding relationships between a...
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