Coordination between aminoacylation and editing to protect against proteotoxicity.

doi:10.1093/nar/gkad778

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Article

Coordination between aminoacylation and editing to protect against proteotoxicity.

Nucleic acids research - 27 Oct 2023

Zhang Hong, Murphy Parker, Yu Jason, Lee Sukyeong, Tsai Francis T F, van Hoof Ambro, Ling Jiqiang

Abstract excerpt

Aminoacyl-tRNA synthetases (aaRSs) are essential enzymes that ligate amino acids to tRNAs, and often require editing to ensure accurate protein synthesis. Recessive mutations in aaRSs cause various neurological disorders in humans, yet the underlying mechanism remains poorly understood. Pathogenic aaRS mutations frequently cause protein destabilization and aminoacylation deficiency. In this study, we report that...

Topics

Humans
Amino Acyl-tRNA Synthetases
Aminoacylation
Mutation
RNA, Transfer
Saccharomyces cerevisiae
Threonine-tRNA Ligase
Proteotoxic Stress

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Identifiers

PMID: 37742077
DOI: 10.1093/nar/gkad778
PMCID: PMC10602869

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