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Article

The histone H3-K27 demethylase Utx regulates HOX gene expression in Drosophila in a temporally restricted manner.

Development (Cambridge, England) - 1 Aug 2013

Copur Ömer, Müller Jürg

Abstract excerpt

Trimethylation of histone H3 at lysine 27 (H3-K27me3) by Polycomb repressive complex 2 (PRC2) is a key step for transcriptional repression by the Polycomb system. Demethylation of H3-K27me3 by Utx and/or its paralogs has consequently been proposed to be important for counteracting Polycomb repression. To study the phenotype of Drosophila mutants that lack H3-K27me3 demethylase activity, we created Utx(Δ), a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23900545
DOI: 10.1242/dev.097204
PMCID: PMC3912917

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The histone H3-K27 demethylase Utx regulates HOX gene expression in Drosophila in a temporally restricted manner.PMID 23900545Read ↗

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